The Bionic Bioreactor Company

The first ever solution to controllable & scalable cell therapy manufacturing.

Our Bionic Bioreactor

Introducing ComfyCell

A whole new approach to stirred-tank bioreactors for 3D cell therapy manufacturing.

Maximum Cell Yield

Enabled by minimal shear forces, no foam formation, decreased culture time & high medium efficiency.

Application Agnostic

Designed to manage applications across various cell types & process modalities, from suspension to adherent cells and from expansion to differentiation.

Real Scalability

The concept of geometric similarity facilitates linear scale-up from 100 mL to 200 L with consistent process conditions.

All For Quality

Low shear forces, uniform mixing conditions and precise process control ensure consistent product quality - from batch to batch.

Our Artificial Lung

Powered by our unique Membrane Stirrer technology

The BioThrust Membrane Stirrer aerates the cell culture bubble-free & minimizes shear forces with gentle mixing.

Low Shear Stress

Gas-transfer through diffusion enables shear-stress free cell cultivation.

Homogeneous Cultivation Conditions

Optimal mixing conditions by CFD-optimized system-design, across all volumes.

Unsurpassed Gas Transfer

Vast membrane area delivers maximal kLa rates - with constant CO2-stripping.

Perfusion System

Process intensification via in-situ perfusion system (in development) and or Fed-batch process.

Broad Range

Of Applications

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The Membrane Stirrer (r) gently mixes the media while providing cells with gases and nutrion needed. Conventional STRs (l) destroy cells through bubble aeration.

Cell Types

Up to 3mm large organoids cultivated over 35 days in 2L

Compared to conventional runs, our Membrane Stirrer achieved the closest to in-vivo results (lung organoids) our academic partner ever measured, producing 3mm large organoids and 100% living cells inside the structure after a process period of 35 days

Cell Types

More than 30 mn cells/mL without additional oxygen

In a benchmark run with a thoroughly optimized conventionally sparged process, the Membrane Stirrer in the first run achieved the same top-notch cell density, but without the need to add any oxygen to the input gas.

Cell Types

More than +200 % increased process yield

Compared to a conventional stirred-tank system, our Membrane Stirrer doubled the achieved cell density and increased production volume by further 30% due to foam avoidance.

Cell Types

Viable cell density increased by almost 50%

Human iPSCs were expanded with remarkable success, reaching an impressive expansion factor of 65! Benchmarked against a conventional bioreactor, our system delivered outstanding performance with a threefold increase in total cell numbers—surpassing an incredible 1.6 billion cells!