The Bionic Bioreactor Company

The first ever solution to controllable & scalable cell therapy manufacturing.

Our Bionic Bioreactor

Introducing ComfyCell

A whole new approach to stirred-tank bioreactors for 3D cell therapy manufacturing.

Maximum Cell Yield

Enabled by minimal shear forces, no foam formation, decreased culture time & high medium efficiency.

Application Agnostic

Designed to manage applications across various cell types & process modalities, from suspension to adherent cells and from expansion to differentiation.

Real Scalability

The concept of geometric similarity facilitates linear scale-up from 100 mL to 200 L with consistent process conditions.

All For Quality

Low shear forces, uniform mixing conditions and precise process control ensure consistent product quality - from batch to batch.

Our Artificial Lung

Powered by our unique Membrane Stirrer technology

The BioThrust Membrane Stirrer aerates the cell culture bubble-free & minimizes shear forces with gentle mixing.

Low Shear Stress

Gas-transfer through diffusion enables shear-stress free cell cultivation.

Homogeneous Cultivation Conditions

Optimal mixing conditions by CFD-optimized system-design, across all volumes.

Unsurpassed Gas Transfer

Vast membrane area delivers maximal kLa rates - with constant CO2-stripping.

Perfusion System

Process intensification via in-situ perfusion system (in development) and or Fed-batch process.

Broad Range

Of Applications

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The Membrane Stirrer gently mixes the media while providing cells with gases and nutrion needed

Cell Types

First scale-up of iPSC-based organoid differentiation process to 2 L

Compared to a conventional stirred-tank system, our Membrane Stirrer doubled the achieved cell density and increased production volume by further 30% due to foam avoidance.

Cell Types

More than 30 mn cells/mL without additional oxygen

In a benchmark run with a thoroughly optimized conventionally sparged process, the Membrane Stirrer in the first run achieved the same top-notch cell density, but without the need to add any oxygen to the input gas.

Cell Types

More than +200 % increased process yield

Compared to a conventional stirred-tank system, our Membrane Stirrer doubled the achieved cell density and increased production volume by further 30% due to foam avoidance.

Cell Types

Experiments & evaluation ongoing

Stay tuned for further updates & publications

Cell Types

Experiments & evaluation ongoing

Stay tuned for further updates & publications

Cell Types

Experiments & evaluation ongoing

Stay tuned for further updates & publications

Cell Types

Experiments & evaluation ongoing

Stay tuned for further updates & publications

Cell Types

Experiments & evaluation ongoing

Stay tuned for further updates & publications

Cell Types

Experiments & evaluation ongoing

Stay tuned for further updates & publications

Cell Types

Experiments & evaluation ongoing

Stay tuned for further updates & publications

Cell Types

Experiments & evaluation ongoing

Stay tuned for further updates & publications

Cell Types

Experiments & evaluation ongoing

Stay tuned for further updates & publications

Process Modalities

Adherent Cells

Grow your adherent cells (such as MSCs) on microcarriers that are gently kept in motion by the Membrane Stirrer.

Process Modalities

Suspension Cells

Leverage the homogeneous, gentle mixing and gas supply of our Membrane Stirrer for a physiological cultivation of your suspension cells.

Process Modalities

Spheroids (Cell Aggregates)

Manage the size and growth of your three dimensional cell aggregates and spheroids with the precisely controllable shear force induced by the Membrane Stirrer.

Process Modalities

Differentiation Processes

Perform the whole process from cell expansion to differentiation in our ComfyCell Vessel. The currently in development in-situ perfusion system will enable a complete media exchange and the automatic supply of specific substances to trigger differentiation.

Process Modalities

In-situ Perfusion

Leverage the options for continuous supply of nutrients and media exchange through the (currently in development) perfusion system for optimizing cell density and maximizing yield.

Discover Our Application Studies

See Application Studies

Our Advocates

“With the Biothrust membrane stirrer, we were able to scale up cardiac differentiation of iPS cells in stirred bioreactor with the first attempt. This novel technology paves the way for our translational studies to treat cardiac infarction by stem cell-based cell therapeutics.”

Priv.-Doz. Dr. Kurt Pfannkuche

University of cologne

“It is our mission to manufacture extracellular vesicle products from conditioned media of MSCs in a scaled and robust manner. Among others a reliable upstream processing procedure is needed. Here, we focus on the bionic biorector concept of BioThrust, which we consider as the most promising 3D bioreactor process for our purposes."

Prof. Dr. Bernd Giebel

University Hospital Essen

Experience The Comfycell Platform

Developed to meet your specific need, from reusable to single-use, from lab to commercial scale.

Volume

250 mL

Achieveable Cell Number

30 BN

Get Your ComfyCell

Volume

2L

Achieveable Cell Number

240 BN

Get Your ComfyCell

Volume

10L

Achieveable Cell Number

1.200 BN

Get Your ComfyCell

Volume

250 mL

Achieveable Cell Number

30 BN

Get Your Comfycell

Volume

2L

Achieveable Cell Number

240 BN

Get Your Comfycell

Volume

10L

Achieveable Cell Number

1.200 BN

Get Your Comfycell

Volume

200L

Achieveable Cell Number

24.000BN

Get Your Comfycell

Experience Comfycell for yourself.

Convince yourself of the new generation of bioreactors - short delivery times, attractive financing models, and process experts by your side make getting started as easy as possible for you.